Tag: Anti-Aging

Posted on by — Leave a comment

Anti-Aging Biohacks for Athletes of Any Age

ES EDM BLOG 0998f27a 1601 40de 8535 14306a96657f

By: M.G. Thibault. Edited by Ryan McTeigue

Whether you are in your 20’s or whether you are in your 50’s it doesn’t matter. The following hacks below won’t just make you feel younger, they will help your body regenerate, recover and for the ladies there is even some beauty biohacking thrown in here. These trends in Age-reversal and body amplificationcome and go especially with new scientific discoveries and advancements in medicine.

However, the best way to find out which modality is right for you is through careful research and professional consultation so you can discuss your goals and customize a hormone and cellular enhancing program tailored to your lifestyle, genetics, needs, and budget.

Here are the most promising non-invasive anti-aging treatments and devices predicted to go big according to our Intel’s forecast.

Infrared Sauna

Infrared Sauna. Scientists at Stanford-Burnham Prebys Institute confirms that sauna use have beneficial effects on health and longevity. What happens is when you expose the body to high temperatures of about 120°-180° F, it creates heat shock proteins and stimulates the lymph system, which detoxifies the system and increases microcirculation. Far Infrared saunas (FIR) are waves of energy, entirely invisible to the naked eye, which infiltrate the surface of the skin where they slightly elevate the body’s surface temperature. FIR are shown to reduce inflammation and oxidative damage, and has the potential to alleviate health conditions that arise with aging.

https://www.sciencedaily.com/releases/2017/02/170215084050.htm

https://www.hightechhealth.com/longevity-benefits/

Stem Cell Facelift. This revolutionary treatment provides the regenerative benefits of stem cell therapy for anti-aging purposes, but entails no surgery and no downtime. A new study finds that after just a few weeks, stem cell treatment eliminates the skin’s sun-damaged elastin network, and replaced with normal, undamaged tissues.

Basically, stem cells migrate to sites of inflammation to dramatically calm down the inflammatory cascade and then lay down a new cellular framework. This treatment yields dramatic skin renewal and a natural lift that can last 3 years.

https://www.sciencedaily.com/releases/2020/05/200528160510.htm

https://journals.lww.com/plasreconsurg/Abstract/2020/06000/Photoaged_Skin_Therapy_with_Adipose_Derived_Stem.12.aspx

Endermologie

Endermologie. Endermologie is a noninvasive mechanical body-contouring used in the treatment of cellulites. Here the cellulite-affected skin is sucked between the rollers and kneaded for approximately 34-45 min. Endermologie was initially developed in the late 1970s in France to soften scars and standardize physical therapy; however, other benefits were seen in patients treated with the LPG machinesuch as improvement in body contour and skin texture, reducing the appearance of cellulite and retaining the youthful suppleness of the body.

https://www.tandfonline.com/doi/abs/10.1080/14764170510037761

https://pubmed.ncbi.nlm.nih.gov/9502849/

Bioidentical Hormone Replacement Therapy

Bioidentical Hormone Replacement Therapy. Bioidentical hormone replacement therapy (BHRT) is a popular modality when it comes to effectively treating hot flashes, mood swings, low libido, and a decline in energy- all of which are symptoms that accompany aging.

Our production of certain hormones begins to decrease as early as our mid 30’s. As one gets older, this decrease in certain hormones changes the way cells and tissues function leading to a myriad of uncomfortable symptoms. BHRT is also a reliable treatment for osteoporosis, thinning hair, poor memory, and other forms of chronic inflammation, that may be observed in both men and women.

BHRT helps correct hormonal deficiencies by providing the body with hormones that have the exact same chemical and molecular structure as those endogenously produced by the body. BHRT is a perfect example of how rejuvenation treatments can help clients age more gracefully and painlessly. BHRT has gotten a lot of attention in recent years as they promise a “natural” solution to hormone issues. One example is Biotropin® HGH synthesized via recombinant technology, which has the exact protein structure of your natural growth hormone, and is made up of 191-amino acids.

A Biotropin® HGH replenishment course boosts Somatropin levels and effectively stimulates tissue repair, cell renewal, and sustain brain and other organ functions thus alleviating the typical symptoms that come with ageing.

https://www.healthline.com/health/bioidentical-hormone-replacement-therapy

https://www.onlinebiologynotes.com/production-human-growth-hormone-hgh-recombinant-dna-technology/

Posted on by — Leave a comment

Circadian Rhythm and Rejuvenation. How Re-Setting The Rhythm Can Potentiate Your Entire Body

ES EDM BLOG 1964e506 c777 4bb0 bcb6 26fcafcb8ba7

By: M.G. Thibault. Edited Ryan McTeigue

Your Circadian rhythm controls many aspects of your health from sleep to heart rate, hormone secretion, blood pressure, neurological function, and metabolic routes. As you can see many things which can either improve of decrease an athletes performance.

Today, researchers are learning that the circadian rhythm can also be a new target to help rejuvenate the whole body and extend lifespan. This area of research holds so much potential that lab studies from MIT discovered a link between a healthy circadian rhythm and the constant rejuvenation of an organism. Scientists are positive that by enhancing the body’s circadian cycle, one can prevent and treat diseases not only due to aging but disorders that arise from very active (fitness lovers) or strenuous lifestyles (most humans on earth).

You can’t really exaggerate the importance of this research since many health conditions arise from the disruption of our circadian rhythms especially in these modern times. These increasing disturbances in one’s “body clock” is strongly linked with inflammatory states including neurodegenerative diseases.

Whether disorders in the body arise from stressful daily routines, environmental toxins, excessive physical demand, or simply from aging, at the molecular level, thanks to our scientific community, a person can now restore the body’s circadian rhythm to a more youthful state and effect complete rejuvenation in the body.

https://news.mit.edu/2013/the-link-between-circadian-rhythms-and-aging-0620

https://pubmed.ncbi.nlm.nih.gov/27885006/

Based on the ongoing stream of confirmatory data, there are particular compounds that can help synchronize and restore the proper operation of the body’s circadian rhythm. This article will prove to be of great value if you feel out-of-sync with your current sleeping habits. This article is for the following person who is:

– Consistently working out

– Regularly engaging in sports or outdoor activities

– Involved in mentally demanding tasks as part of the job

– Constantly multi-tasks in a daily basis

– Looking to increase their productivity levels

– Gearing up for a more challenging workload ahead

– Experiencing problems due to inflammatory conditions

– Already feeling age-related effects in performance

If one of more factors on this list describe YOU, your priority right now is to regain control over the proper function of your circadian rhythm in order to re-claim your essential health and rejuvenate your body to its highest level. Below we outline a few hacks which can greatly help with this task::


1. Melatonin

Scientists have found that we can keep our circadian clock in sync through melatonin supplementation. This unique nutritional approach targets both central and peripheral clocks to regulate circadian rhythm. When the brain’s pineal gland secretes melatonin, this helps normalize hormone production, neurotransmitter functions and healthy sleep patterns.

A 2017 study shows that daily supplementation of 10 mg of Melatonin in subjects with obesity decreased oxidative stress and facilitated body weight reduction while improving the body’s antioxidant defence. This factor translates to healthy, normal individuals as well.

https://pubmed.ncbi.nlm.nih.gov/25287733/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632922/

2. SIRT 1 activators

Researchers have shown that SIRT1 (Sirtuin) helps regulate circadian rhythm and protect against the diseases of aging. The SIRT1 gene is also shown to protect against diseases of aging and plays a key role in controlling the body’s circadian rhythms. Conversely, loss of SIRT1 function impairs circadian control in young mice, mimicking what happens in normal aging. Activating the SIRT1 pathway to sustain adequate circadian control and thus reverse aging is a probable therapeutic target that Regenerative Medicine is currently looking into.

By activating the SIRT1 pathway, damage in our DNA created by environmental factors, stress, energy deprivation, and toxins that the body accumulates are constantly being replenished and cell division continues to ensue.

Sirtuin-activating compounds include ginseng, resveratrol, quercetin, polyphenols found in bitter vegetables, cacao, curcumin, ginger, and DHA sourced from fatty fish, eggs, and algae. So ensure you add greens to your daily meals and consider into adding the aforementioned herbal and food supplements into your weekly routine – test it out and see if you feel better after at least 14 days of consistent usage.

https://pubmed.ncbi.nlm.nih.gov/32084459/

3.Rev-erb-α Agonists

Rev-erb-α is critical for the proper timing of the core clock machinery, regulating many metabolic functions, which include lipid and bile acid metabolism, gluconeogenesis, and the body’s inflammatory response. Rev-erb-α ligands, specifically agonists or activators, modify the transcriptional activity (telling the body what to do) and suggest that Rev-erb-α may serve as a promising target for the treatment of circadian alterations of metabolic pathways.

Rev-erb-α modulation was proven to be efficient in phase-advance sleep disorders commonly seen in the aging population, while it helps correct delayed circadian rhythms, frequently seen in individuals with super-active or very stressful lifestyles. In short compounds such as SR9009 can help to balance the circadian rhythms in both sleep deprived and overly-active individuals – assisting in rejuvenation and regeneration of the entire body. Leading to more energy to train, work and do more of the things you love doing!

Rev-Erbα agonists such as Hyper Lean SR9009 has been proposed to coordinate circadian metabolic responses while maintaining the timely schedule of wakefulness, sleep, body temperature, and hormone regulation which in turn facilitates a myriad of biochemical pathways. Therefore, Rev-erb-α ligands may be useful in resetting the Circadian clock into its youthful resonance and efficiency.

You can find Elite Sarms Rev-erb-α Agonist Hyper Lean® (SR9009) here.

Sweet dreams,

-ES


https://www.elitesarms.com/collections/individual-sarms/products/hyper-lean-sr9009

https://journals.physiology.org/doi/full/10.1152/japplphysiol.00570.2009

Posted on by — Leave a comment

Diverse Rejuvenation in a Bottle – Decavar MK-2866

ES EDM BLOG a17a6929 1270 4e37 8649 3cafae2fee24

By: M.G. Thibault. Edited: Ryan McTeigue

While scientists continue and progress in SARMs research, studies are increasingly assessing how to push the boundaries of SARMs development to maximize their potency, bioavailability, half-life and tissue selectivity, while minimizing side effects. Over 50 years of androgen research has resulted to one of the most cutting-edge SARM – MK-2866 (Decavar®).

MK-2866, otherwise known as Ostarine or Decavar® is a compound developed by the company Gtx Inc. In 2009, initially designed to fight muscle wasting diseases like cancers in all forms. MK-2866 went through numerous phases of trials from roughly 2005 through 2014. MK-2866 was studied and tested for its effectiveness against different medical conditions. It has a molar mass of 389.33g/mol and its melting point is 270°F to 277°F or 132°C to 136°C, rendering its stability even at higher temperatures, scientifically MK2866 is a sturdy compound.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907129/

https://www.elitesarms.com/collections/individual-sarms/products/decavar-mk2866

Pharmacodynamics of MK-2866

MK-2866 is an orally available non-steroidal SARM (all Sarms are non-steroidal despite having steroid like results, an amazing fact in and of itself) that has shown promising results in both preclinical and clinical trials, and is currently being studied for a number of different indications.

MK-2866, popularly known as Decavar is a selective androgen receptor modulator, which aims to increase the growth of muscle mass and improve strength. This main action occurring through the drastic increase of repair and rejuvenation of collagen. Collagen being the material located throughout the body in: muscle, bone, tendons, ligaments, organs, blood vessels, skin, intestinal lining and all other connective tissue. It’s this collagen increase and modulation of repair that attributes to Ostarines muscle building, muscle and joint rejuvenation, muscle conditioning and strength increasing properties. The compound also prevents muscle wasting that occurs in diseased states, fasted states and accompanies aging.


What is MK-2866’s mechanism of action?

MK 2866 is highly selective and only binds to bone and muscle androgen receptors while simultaneously modulating collagen as previously mentioned. What is so impressive about this novel substance is that it has multi-functional properties and the product can be used for not only building muscle mass, but for the regeneration of joints, muscles, and connective tissues. The substance proves to be a great bone regenerating supplement fortifying bones and prominently enhancing the strength and density of them. Structural improvements in post-menopausal female subjects were proven in lab testing resulting in bone improvements such as increased bone mineral density and increased bone volume density. You can then imagine the bone fortifying results a trained athlete will receive when the application of MK2866 is introduced to their training regime.

A 2019 study in the University of Life Science researched the effect of MK-2866 on fat cells of lab rats. The research results demonstrated:

The stimulation of androgen receptor expression. Whereby the metabolism was improved by facilitating the mRNA and protein expression of Androgen Receptors.

Decavar MK-2866 stimulates lipolysis. Investigations found that as little as 1 μM (micromole) of MK-2866, roused lipolysis in isolated rat adipocytes (fat cells) after just 120 and 480 minutes of incubation.

MK-2866 inhibits lipogenesis (fat creation). In animal studies MK-2866 displayed a marked effect on the halting of glucose (carbohydrates) to lipids (fats) in the lab. When MK-2866 is added to animal adipocytes (fat cells), it also inhibited (ceased or reduced) the rate of fat creation in those test subjects.

Decavar MK-2866 modulates the expression and secretion of leptin. Leptin is a hormone that sits in the stomach lining and basically tells the brain when you are full. When this signal is disrupted one will continue to eat beyond the bodies energy requirements – and disrupted leptin levels are the culprit of these signals to the brain telling one to eat more.

Leptin levels being low or disrupted (usually via consuming inflammatory creating foods) are directly associated with adipose tissue mass (fat tissue mass). Leptin concentrations are directly connected to cases such as obesity and cardiovascular diseases such as hypertension and myocardial infarction, both of which are more commonly seen in the aging population. Experiments showed that by administering MK-2866 to isolated rat adipocytes, leptin gene expression was normalised.

https://pubmed.ncbi.nlm.nih.gov/29785666/

http://www.jpp.krakow.pl/journal/archive/08_19/pdf/10.26402/jpp.2019.4.04.pdf

https://www.elitesarms.com/collections/individual-sarms/products/decavar-mk2866


Dosing

Most MK-2866 cycles last between 8 and 12 weeks. The cycle for beginners on average begins with a lower dosage of 10mg. With more experience in the use of SARMs, the dose can be increased, but the entire cycle should not last more than 12 weeks.

Decavar® is highly anabolic especially when paired with a well-calculated balanced diet including adequate, quality protein, good fats and complex carbs. Leaving the weekends or set days to eat outside these healthy foods and replenish the inner child through “cheat meal”. Then jumping straight back onto the horse and riding the nutrient rich diet once again. For us normal to serious training folk a good nutrition split is 80/20; 80% clean nutrition with 20% for not so clean, not so nutrient dense cheat meals. But that’s a whole other blog…….


Future Trends

The research community is now looking on esterification of MK-2866, a process in which the compound is altered to increase the half-life and biological action of the compound. So Instead of taking 1 dosage of Decavar® daily this could lead to only having to take 3, 2 or 1 dosages in a weekly period. Although this process is in the early experimental stages, the pharmacological optimization of one of the most documented and widely used SARMs – Decavar® (MK2866) offers a fresh take and may open up more exciting avenues for SARMs research.

Posted on by — Leave a comment

Elite Sarms Rejuvenation Biohacking Tech

ES EDM BLOG 80275cb0 1c01 4680 b69a 7768398acab8

By: M.G. Thibault Edited by Ryan McTeigue

Aging leads to a series of changes in an organism as deep as the cellular level. Although, the mechanisms that underlie aging are poorly understood, innovations in science continue to identify factors that explain the decline in fitness and the rise of different health problems that go with advancing age.

While slowing the aging process remains to be a popular topic, what’s even more compelling is the subject of Age-reversal; this is referred to as Rejuvenation.

Rejuvenation is a process that not only defers aging, but literally reverts it- resulting in a younger cell, tissue, or body. Rejuvenation includes diminishing all the damages your body has accumulated throughout its lifespan, and erasing the hallmarks of a matured age. Come to think of it, successful rejuvenation not only leads to the extension of life but ultimately to eternal youth! Does it look like something you’d be interested in? Read on…

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.13483

Cell-regenerating Nutrition

Our body is an extraordinary machine and its primary fuel are the nutrients we get from the food we eat on a daily basis. By purposefully consuming foods that have ‘supercharging compounds’, a person can promote the rapid regeneration and restoration of some of the body’s most important tissues and organs.

Nerve-regenerative substances:
A 2010 study published in the journal Rejuvenation Research, for instance, found a combination of blueberry, green tea and carnosine have neuritogenic (i.e. promoting neuronal regeneration) and stem-cell regenerative effects in an animal model of neurodegenerative disease. Other researched neuritogenic substances include: curcumin, Lion’s Mane Mushroom, and apigenin, a plant flavonoid usually found in celery.

On the other hand, you can stimulate liver mass regeneration and function by ingesting via supplements that focus on liver renewal such as Korean Ginseng, Rooibos, Vitamin E, and Carvacrol, a compound found in oregano.

https://pubmed.ncbi.nlm.nih.gov/20586644/

http://www.thehealersjournal.com/2014/09/25/how-to-regenerate-your-bodys-cells-with-food-and-herbs/

https://pubmed.ncbi.nlm.nih.gov/24266378/

https://pubmed.ncbi.nlm.nih.gov/30949912/

Age-defying Exercises

According to a medical article, exercise improves muscle health by renewing the powerhouse of the cells: the mitochondria. Mitochondria are vital to the proper functioning of our bodies, and the improvement of our overall health and longevity.

Aerobic exercise, in particular, positively affects the mitochondria through a process called “mitophagy.” Mitophagy is a mechanism by which damaged or defective mitochondria are selected and removed, usually after a period of stress. This keeps skeletal muscle healthy and strong by improving the mitochondrial quality of the muscle fibers.

If you are a gym person- the treadmill, elliptical or rowing machine may be your go to equipment to achieve your fill of cardio exercises. Likewise, if you prefer the outdoors, you may try swimming, soccer, triathlons and cross country skiing as enjoyable alternatives to improve your aerobic capacity.

https://www.medicalnewstoday.com/articles/319532#Exercise-promotes-mitophagy-in-mice

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798/

Supplements for Age-Reversal

In the ever-evolving world of Cellular rejuvenation, supplements are constantly being discovered and re-formulated. So far, the following are considered to be on top of the food chain when it comes to reverting the aging process:

There are secretagogues, which stimulates the endocrine glands’ ability to secrete more Growth Hormone, which in turn affects the major metabolic pathways in the body, such as fat oxidation, glucose utilization, muscle synthesis, and collagen production just to name a few.

Rejuvenation procedures in private clinics almost always integrate bio-identical Somatropin injections as part of their hormone optimization courses, while others employ drips and infusions of high doses of Vitamin C to regenerate hormones that have degraded. A powerful electron donor, vitamin C has the capacity to provide electrons in order to resurrect the form and function of estradiol, progesterone, and testosterone.

https://www.elitesarms.com/collections/anti-aging/products/gh-pep-mk677

https://www.healthline.com/health/vitamin-c-injection

Current Modalities on Rejuvenation

Ablative laser resurfacing is generally considered to be the gold standard for the rejuvenation of facial photo-damage and scarring. The procedure is a wounding laser that gets rid of the thin outer layer of skin (epidermis) and heats the underlying skin (dermis), which then triggers the growth of new collagen fibers. As the epidermis heals and regrows, the treated area appears smoother and tighter.

Neck rejuvenation mainly targets skin laxity, that often increase with age due to progressive loss of bone mass, increased subcutaneous fat, and loosening of the connective tissue framework. Using unipolar and bipolar radiofrequency or Infra-red light, sagging skin in the neck area is targeted yielding a tighter, firmer, and younger looking skin just after a few sessions.

A new paradigm for human cell rejuvenation, cellular reprogramming proves to be a promising route when it comes to retracting the procession of aging, which is the basis of rejuvenation.

This is the most recent breakthrough in the anti-aging field, which involves a genetic or chemical method to reverse the epigenetic age of cells. This genetic code instructs mature, specialized cells to read the right genes at the right time, as though they were young again. The factors scientists are currently using to reprogram these mature cells are called Yamanaka factors, which can turn back an adult cell into a young, pluripotent stem cell. Literally!


https://www.mayoclinic.org/tests-procedures/laser-resurfacing/about/pac-20385114

https://www.researchgate.net/publication/225927112_Treatment_of_Neck_Laxity_with_Radiofrequency_and_Infrared_Light

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960911/

Posted on by — Leave a comment

Hacking Your Bioage With NAD+

WhatsApp Image 2021 06 23 at 15.13.16

By M.G. Thibault
Edited by Ryan McTeigue

Aging is a natural and organic process that everyone undergoes. Both our bodies and mind go through cycles of changes throughout our life. As we age, our cells have a lesser capacity to divide and multiply, some lose their function, and eventually deteriorate. This is the scientific meaning of ageing

The dilemmas that come with aging

As our age advances, wrinkles become more prominent in our skin, our hair thins and loses pigmentation, and our memory is not as retentive. More importantly, we feel a decrease in energy and strength; we become more susceptible to diseases, while abnormalities and dysfunction begin to show within our body.

So, when this article mentions about “hacking” your biological age, this means we are providing you with science-based information that leads to some adjustments in your lifestyle and diet, which can intervene with these signs and symptoms of aging.

The Role of “Nutrigenomics”

When we talk about Biohacking, we have to mention its close associate, “Nutrigenomics.” This term supports the idea that our body’s total genetic expression can be optimized by taking the right nutrients that influence our overall health over time.

The thing is, genes may be critical for determining inherent abilities, but Nutrition can modify the extent to which different genes are expressed and thus modifies whether an individual reaches the potential established by their genetic pre-disposition.

This emerging knowledge can transform nutrition and dietary practices to optimise health, promote longevity, and prevent or even treat certain diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121546/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137135/

First off, we’ll identify the “poor-quality” foods that induce inflammation. Some studies consider aging as a chronic inflammatory state, so one of the best anti-aging hacks would be to stop eating junk food (such as fried foods) and start incorporating more anti-oxidants and anti-inflammatory foods in your diet.

Avoid trans fats, that easily produce cancer-causing free radicals and literally slow the body down. It will also benefit you to refrain from eating too much sugar and processed carbohydrates (like pasta, bread, and pastries) as this may lead to chronically high insulin levels that positively correlate with age-related diseases including diabetes and heart diseases.

Treated meats like hot dogs, bacon, and pepperoni are usually high in nitrates, which also lead to inflammation. Moderate drinking (a 5-ounce glass of red wine per day, 5x a week) may be good for your heart, but heavy drinking will only speed up the aging process.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457053/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326908/

https://www.ncbi.nlm.nih.gov/pubmed/12070110


Boosting NAD+ levels

Nicotinamide Adenine Dinucleotide otherwise known as NAD+ is a chemical compound, which is found in essentially every cell of the body, and produced in abundance during adolescence all the way up to early adulthood. Its main function is to facilitate healthy brain function, regulate metabolism, repair damaged DNA, and strengthen our cell’s defences. Like most compounds secreted by the body, NAD+ levels start to decrease as we age.

Recent lab tests on animals have shown that raising NAD+ levels may help reverse signs of aging and reduce the incidence of many chronic diseases. You can boost your NAD+ levels by:

1. Exercise. Daily workouts require more NAD+ for energy, and your body responds to increased demand by producing it.

2. Raw foods that contain vitamin B, like avocados, steamed fish, whole grains, and nuts can boost NAD+ levels. Consider adding fermented foods and drinks to your diet like sauerkraut and kombucha. These are rich in NAD+ and also effective in easing persistent bloating and chronic joint pain.

3.Oral NAD+ supplements. One article shows that supplementation of Nicotinamide Riboside (NR, 500 mg, 2×/day), a NAD+ precursor, effectively stimulates NAD+ metabolism in healthy middle-aged and older adults.

4. NAD+ infusions. The Intravenous route promotes higher bioavailability, compared to oral supplements meaning a fuller dosage enters the body to help restore the mitochondria, and renew power at the cellular level. Specialised health and anti-aging clinics may have this available, shop around the internet to find one near you if you are interested.

https://www.nature.com/articles/s41467-018-03421-7

5. Growth Hormone Mimetics. GH Pep® (MK-677) is a growth hormone secretagogue, which amplifies the body’s natural release of growth hormone (GH) and insulin-like-growth-factor 1 (IGF-1). Among their many benefits such as lean muscle gains, accelerated fat loss, and tissue repair, the increase in GH and IGF-1 levels regulate mitochondrial mass and function and contribute significantly to mitochondrial biogenesis, respiration and ATP production.


How does this relate to boosting NAD+ levels?

A Study from the University of California demonstrates that the mitochondria in cells create NAD from the nicotinamide mononucleotide (NMN), one of its precursors. This explains why NAD+ levels decline with mitochondrial dysfunction aka slow metabolism and reduced NAD+/NADH ratio is implicated in mitochondrial disorders, as well as during aging.

As far as anti-aging goes, Elite Sarms product: GH Pep® (MK-677) is a remarkable anti-aging supplement since it not only boosts your growth hormone and IGF-1, sustaining your hormone profile in a state of perpetual youth, it also increases the production of your NAD+ which you now know is another Key Level Player in the quest for the fountain of youth.

https://www.elitesarms.com/products/gh-pep-mk677?_pos=1&_sid=0fa73c6c8&_ss=r

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/

https://www.mdpi.com/2073-4409/9/6/1384/htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013257/

https://clintransmed.springeropen.com/articles/10.1186/s40169-016-0104-7

Posted on by — Leave a comment

How To Reverse The Aging Process 
(A Fact-Based Article)

WhatsApp Image 2021 03 18 at 13.10.27

By M.G Thibault
Edited by Ryan McTeigue

Why do we age? It’s no big secret that people put tremendous effort, time and money to try and reverse the effects of aging and try various methods to appear vibrant and youthful. As aging is inescapable, our struggle to become perpetually young is wasted energy. However while we can’t turn back the hands of time, it has been scientifically proven through bio-age analysis, that we can reverse our biological age. This blog focuses on the mitochondria (energy producers of the cell) and the latest information to come out about the link between boosting mitochondria and its effects on anti-aging.

Recently, scientists have discovered that changes in the mitochondria of our cells pose as a potential central regulator of the aging process. Research suggests the link between anti-aging and healthy mitochondria, has to do with the mitochondria’s influence in our body’s immune system, the fact it produces almost all of our cells Adenine triphosphate (ATP) which supplies the cells and subsequently the entire body with energy and the nuclear signalling mitochondria drives that controls our circadian rhythm – the bodies automatic sleep-wake cycle.

https://pubmed.ncbi.nlm.nih.gov/30059016/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118639/

Following the lead of the latest research studies, health and fitness proponents caught wind of this fact and are now focusing on the mitochondria as an effective route to delay the biological clock and here’s what we have found out so far:

1. High intensity interval training (HIIT)

High intensity interval training (HIIT) is a great strategy to boost mitochondrial function. A 2017 study in cell metabolism found that the HIIT style training caused cells to make more proteins for the mitochondria, which revitalizes them. HIIT training created a 49% increase in mitochondrial capacity for young, healthy adults in the study: the older volunteers experienced a whopping 69% increase!!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540458/

2. Grounding (or earthing)

Grounding (or earthing) is the habit of attaching bare skin to the Earth such as soil or grass. They found that the mitochondria in the grounded subjects are less stressed and not working so hard to produce energy due to the body’s state of homeostasis. Believe it or not, there is reliable scientific data behind this. A meta-analysis demonstrates that Grounding could support restorative sleep and help with chronic pain. Another research also noted its significant effects on the immune system and wound healing. So, take off your shoes and get your bare feet on the grass as often as possible.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265077/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/

3. CoQ10

Taking CoQ10 helps the mitochondria with energy production. CoQ10 is an antioxidant that our body naturally produces but gets depleted as we age. By facilitating Adenosine Triphosphate (ATP) production in the mitochondria, CoQ10 maintains the normal functioning of our muscles and body organs especially the brain and heart which require the most fuel.

https://pubmed.ncbi.nlm.nih.gov/24534273/

4. Supplementing with Acetyl-L-carnitine

Supplementing with Acetyl-L-carnitine or ALC provides more than 20% of mitochondrial proteins which helps our cells’ batteries to function properly, including those involved in antioxidant defence and energy production. Moreover, one of the key changes in physiology associated with longevity is an increased acetylation of mitochondrial proteins.

https://pubmed.ncbi.nlm.nih.gov/25660059/


5. Hyper Lean

Taking Elite Sarms – Hyper Lean (SR9009) for drastically Increased Mitochondrial production and improved function is another potent way to increase the body’s energy generators. In muscle, SR9009 encourages the production of new mitochondria while lowering the deterioration rate of older cells and completely removing damaged ones. A study was conducted where lab mice treated with SR9009 showed an increased number of total and active mitochondria. This mechanism was mediated by repressing autophagy (the consumption of the body’s own tissue as a metabolic process occurring in starvation and certain diseases) genes in the muscle cells. Elite Sarms – Hyper Lean (SR9009) also leads to a relative boost in power and longer endurance when the skeletal muscles are at work!

Aside from stimulating the quantitative increase of mitochondria, SR9009 also facilitates their efficiency, thereby promoting the muscle’s fat burning ability by accelerating the metabolic rate.

As a REV-ERB α and β agonist, SR9009 increases the basal metabolic rate and promotes energy balance by regulating the expression of genes related to lipid and glucose metabolism. This is the reason why SR9009 is a popular product among fitness people and athletes. Check out this article to find out more about the fat burning properties of SR9009.

https://www.elitesarms.com/collections/all-products/products/hyper-lean-sr9009

https://pubmed.ncbi.nlm.nih.gov/23852339/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085709/

https://www.elitesarms.com/blogs/news/metabolic-boosters-for-effective-fat-loss

The Final Word: What we’ve now learnt about the mitochondria and how it can address the fundamental mechanism of ageing gives us an opportunity to move beyond old age and perhaps even tackle the problems and health issues that are associated with aging. This can be a phenomenal shift where we stop putting a bandage over the effect of time, but instead get to the roots of ageing which is within our cells. In this way, we can take control of our biology, health and performance as our chronological age-clock ticks into the future.

Posted on by — Leave a comment

Why MK677 Is One of the Best Anti-aging Elixirs on the Market

ES EDM BLOG 4ef2e2e6 b56d 4dba 90ea 6df439239764

Written by: Michelle G. Thibault
Edited by: Ryan McTeigue

Can the aging process be stopped or reversed? If you’ve thought about this, you’re not alone. In fact, this is something that has crossed billions of people’s minds at some point in their life. This problem has even plagued scientists the world over for centuries, in search of the elusive fountain of youth. And while science continues to look for plausible ways to beat the biological clock, the billion-dollar business of anti-aging has come up with different products and modalities to find possible answers to the phenomenon of ageing.

There are many theories of ageing from mitochondrial dysfunction and cellular ageing to environmental factors and/or DNA damage. This article will focus on one of the most studied and strongest theory behind why we age: Hormones.


Hormones and Aging

Could your hormones be ageing you? Proponents of the hormonal ageing theory support that the interplay of different hormones in the body can be one of the most major causes behind the ageing process.

The most documented metabolic pathway involved in ageing is the IGF-1 (Insulin-Like Growth Factor-1) signalling pathway. The decline of this pathway is closely associated with metabolic changes including fatty acid and glucose metabolism slowing down as you grow older. This is also the reason why the body loses its firmness and become saggy and tends to accumulate more visceral fat – which are those soft adipose deposits around the belly area!

Let’s break this down. Do you ever hear older people complain about sleeping problems? That’s because with increasing age, sleep becomes shallower and more fragmented. And there’s a hormone the body secretes when sleeping. It is called: Human Growth Hormone or HGH. When sleep is short and disjointed, HGH secretion decreases.

HGH is very important because it stimulates the liver to produce IGF-1 which is responsible for systemic body growth. IGF-1 has growth-promoting properties on skeletal muscles, cartilages, bones, skin, and every connective tissue in the body! Research studies also show that IGF-1 can regulate cellular DNA synthesis.

Let’s go back to HGH where we first started. What’s interesting is that when the body detects increased levels of HGH, Somatostatin (the word statin is Latin for stop) – a hormone in the hypothalamus, is secreted to inhibit further release of HGH. Hence, it is part of a feedback mechanism, and also goes by the name, growth hormone-inhibiting hormone or GHIH. It’s worth mentioning that when administered in elderlies, Somatostatin causes a significant decrease in sleep time.

https://www.sciencedirect.com/science/article/abs/pii/S0893133X96002448

http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/somatostatin.html

…So let’s review. HGH is a very important hormone because it keeps the cells in our body young and functional. It stimulates IGF-1 which mediates its beneficial effects. As we age, HGH levels decline, part of that is due to short and interrupted sleep that comes with ageing. Somatostatin is also another hormone that modulates HGH release as part of the feedback loop.

Anti-Aging Solutions that Work

The concept that hormones, or lack thereof may cause ageing has triggered a massive interest in the use of Synthetic Human Growth Hormone. These are injectable compounds which really work and had been around for ages. But the challenge lies on finding high quality HGH in a market that is flooded with fake products that can burn your pocket, big time! If you prefer this route, make sure that the product you’re buying has been tested for purity and that is actually contains HGH and is scripted by a Medical Professional if you purchasing in countries that require a script for this peptide.

Another feasible approach from the hormone theory standpoint, would be something that can improve our HGH levels- either by increasing its secretion or preventing its inhibition.

The synthesis of a novel compound called MK677 saw an important milestone in the quest for the fountain of youth. MK-677 is an HGH secretagogue, meaning it increases the secretion of HGH in the pituitary gland. MK-677 is taken orally and mimics the action of ghrelins, which send signals to the brain to stimulate the pulsatile release of Human Growth Hormone (HGH). What’s really amazing about MK-677 is that research studies also show that through the HGH increase, it also causes elevated levels of Insulin-Like Growth Factor 1 (IGF-1). Remember the action of IGF-1 and how it can sustain the health and functionality of our muscle, adipose tissues and organs?

The third mechanism of MK-677 is its ability to reduce Somatostatin release. Yes, the very hormone that prevents HGH secretion when levels get too high in the blood. MK-677, by addressing both sides of the GH equation: Increased secretion and decreased inhibition, is undoubtedly a powerful anti-aging tonic. With a once-daily oral administration, it effectively rejuvenates the GH/IGF-I axis re-creating the physiologic GH profile of a healthy young adult. It doesn’t have any adverse effects such as cortisol elevations or any hormonal suppression.

Based on scientific studies, MK677’s ability to enhance HGH and IGF-1 levels can bring about:

-Lean Muscle Gains

-Improved abdominal Fat Loss

-Enhanced Skin tone and texture

-Increased bone density and Strength

-Dramatic improvement in Sleep Quality

-Significant boost in Immune System

-Accelerated healing of tissue injuries


https://www.elitesarms.com/products/gh-pep-mk677?_pos=1&_sid=4bef00730&_ss=r

https://pubmed.ncbi.nlm.nih.gov/8954023/

https://pubmed.ncbi.nlm.nih.gov/9071975/

https://pubmed.ncbi.nlm.nih.gov/18981485/

https://pubmed.ncbi.nlm.nih.gov/15814848/

Posted on by — Leave a comment

How Human Growth Hormone Makes You Look and Feel Younger

ES EDM BLOG d873dcab cbec 4c5f 9448 ed4fc88dd991

Original Design: Michelle G. Thibault
Re-design: Ryan McTeigue

Once you are born, the biological clock starts “ticking” and you become older each day. Everything in your body including your body parts, skin, organs and hormones levels are on a schedule and each day they become chronologically older. This is just how life works – everything is in a constant state of ageing.

Consequently, ageing comes with a lot of physical changes. These changes present as wrinkling and drying of the skin, bones becoming weaker, muscles becoming less toned and eventually wasting away and hair begins to grey and start to diminish…

So where does HGH come into play in all of this?

Human Growth Hormone (HGH) is perhaps the most popular hormone analogue in the fitness market. Its wide array of uses include bodybuilding, strength enhancement, and in recent years, anti-ageing. This makes HGH the gold standard of therapy among adults.

Just as the name implies, HGH promotes normal growth. It is medically used in children to treat developmental issues such as stunted growth.

Does growth hormone really slow or reverse the effects of ageing? Keep reading for a scientific explanation of what one can expect from HGH – especially when used as a therapy for anti-aging.

Many health and fitness proponents believe that HGH injections, often hailed as the fountain of youth, is an incredible substance that can help alleviate symptoms that come with ageing. Competitive athletes, bodybuilders, and people who are passionate about bio-hacking have discovered that HGH can sustain their strength and youthful physique over long periods of time.

A cycle of HGH initiates a cascade of metabolic events in the body that ultimately reduce the symptoms that accompany the ageing of cells. If the question is: does HGH slow down aging? The answer is – Definitely. HGH delays the ageing process by counteracting the factors that contribute to aging. One of those factors being – low circulating HGH levels in the body.

The Scientific Evidence

A 1990 study was conducted to define the effects of growth hormone on men above 60 years old with decreased levels of insulin-like growth factor. The study revealed that the treatment with HGH reduced the amount of fat stored in the body, significantly increased their muscle mass, increased the bone density and also reduced thinning of the skin which overall improved the general wellbeing of the test subjects.

https://pubmed.ncbi.nlm.nih.gov/2355952/

Excess body fat is always an issue that presents as a challenge – regardless of whatever age range you’re in. If you’re someone younger, it can impede you from achieving your desired physique. But as you age, fat gets deposited in the muscles and bones, which leads to weakness and un-toned muscles. It can also put you at risk for serious cardiovascular diseases.

Body fat is majorly stored in the body through the action of insulin and HGH is a strong antagonist for insulin. HGH binds directly to receptors in the adipose tissues to mobilize them and form free fatty acids. This eventually reduces the amount of fat stored in the body as HGH enables the fat cells to be utilized for energy.

https://pubmed.ncbi.nlm.nih.gov/1916055/

HGH facilitates the uptake of proteins in the muscular tissue to optimize lean muscle gains. It is mainly this mechanism that makes HGH popular in bodybuilding to increase muscle mass. One symptom of advanced age is diminishing muscles and this can be prevented with HGH. It can promote and maintain muscle mass, as well as stimulate collagen synthesis which also improves skin tension thereby reducing the appearance of skin wrinkles.

https://pubmed.ncbi.nlm.nih.gov/29172848/

https://pubmed.ncbi.nlm.nih.gov/20959702/

Ageing also leads to fragile bones that negatively impacts strength. This is also the reason why older people are more susceptible to fractures. Studies have shown that HGH significantly increases the mineralization in the bone. This action is largely mediated by the insulin-like growth factor 1 (IGF-1) which is synthesized in the liver. IGF-1secretion is released by Human Growth Hormone.

https://pubmed.ncbi.nlm.nih.gov/17721072/

This gives the individual an overall sense of wellbeing. The physical and emotional stability one receives on HGH therapy not only prolongs life significantly, it can also preserves confidence and sense of security moving into older ages.

The Bottom Line

By supplementing with HGH, scientific studies and anecdotal evidence support the beneficial effects of this compound to diminish and in some cases, reverse the symptoms of ageing. This gives the individual an overall sense of wellbeing. The physical and emotional benefits one receives on HGH therapy not only prolongs life significantly, it can also preserve a sense of confidence moving into older ages.

HGH Dosage for Anti-Aging

Most doctors usually suggest that a small amount of HGH is needed to benefit from its anti-aging properties. Preferably, a daily dose of 2-3 IU of growth hormone is recommended for anti-aging benefits.

If you are using GH both for its anti-aging and bodybuilding effects or athletic support, daily dosages can range around 4-6 IU/daily.

Elite Sarms product GH Pep also known as MK677 is a growth hormone secretagogue in which a 1ml daily dosage is equivalent to around 2IU of the HGH peptide. What is great about this product is there are Zero injections required as it is an oral product. You can check out GH Pep in the Elite Sarms range here.

Posted on by — Leave a comment

GH Pep (MK677) The Natural GH Enhancer & Anti-Aging Wonder

WhatsApp Image 2020 08 18 at 12.24.58 PM

1. In this following Elite Sarms – INTEL blog we are going to dive into the core science of growth hormone (GH), a naturally secreted peptide called Somatropin, in the body by the anterior lobe of the pituitary gland.

2. Lets chat about the Pituitary Gland for a moment, its role in the body and how important the health of this gland is to our overall physique and performance

3. The Pituitary Gland’s main function is to secrete hormones into your bloodstream. The Gland is a part of the body’s endocrine system. The endocrine system is a series of glands that secrete hormones that regulate metabolism, muscle growth and development, tissue functioning, reproduction, sexual function, sleep and mood.

4. As you can see, the Pituitary Gland is a gland in our body which is the Command & Control Centre for all major hormonal action occurring in our body.

– By understanding this gland and its function within the body, we can then focus on The Pituitary Gland’s optimum health by looking into the lifestyle factors and lifestyle choices that can either decrease or increase the output and health of this important gland.

4.. The amount of Growth Hormone one naturally secretes will depend on several lifestyle factors including but not limited to:

– AGE
– HEALTH
– FITNESS and STRENGTH LEVELS
– NUTRITION QUALITY & WATER INTAKE
– SLEEP QUALITY
– ENVIRONMENT
 (relaxing or stressful)
– STRESS LEVELS
 and ADAPTION TO STRESS

5. You will notice of all the factors above the ONLY factor you DO NOT have control over is your AGE. However! Did you know that you actually have 2 ages? 


6. Yes, it’s true. We all have our chronological age – the number of years we’ve been on earth – which we cannot change, however, we also all have what is called our biological age.

7. Our biological ages are determined by all the factors that affect your DNA. Some of the most important factors include:

– HORMONAL STATE (testosterone to healthy estrogen balance)
– AMOUNT OF LEAN MUSCLE TISSUE ON BODY
– BODY FAT LEVELS
– HEALTH OF ORGANS
– METABOLISM
– INSULIN LEVELS
– BODY’S NATURAL PEPTIDE SECRETIONS

8. Therefore, the TRUE term for anti-ageing is actually ANTI-BIOLOGICAL AGING, as it is impossible to turn back our chronological-age but it IS POSSIBLE to increase our overall health in the areas above (arrow) and REVERSE our BIOLOGICAL AGE. GH Pep® does exactly this by increasing the natural Growth Hormone output of the Pituitary Gland. Yes, it is pretty amazing.

5. There are large Natural pulses of growth hormone from the Pituitary Gland after high-intensity training, during REM sleep, after sexual activity and also first thing in the morning after good rest.
6. Elite Sarms – GH Pep (MK677) is the only Sarm in our range to drastically increase the NATURAL pulses of Growth Hormone from the Pituitary Gland.

7. The natural increase of Growth Hormone caused by GH Pep will be independent of lifestyle factors – meaning there will be an increase of GH regardless if the person has control of all of the above lifestyle factors that affect natural growth hormone output.

8. HOWEVER, add in resistance training, strength training and/or cardio and pump up the intensity! – Then you will really get to see Elite Sarms – GH Pep shine in all its glory.

9. The first thing one will notice is waking up in the morning FRESH. The New Growth Hormone pulses from taking Elite Sarms – GH Pep goes to work in the body speeding up the repair of connective tissue, muscle and bone and driving cellular rejuvenation.

10. A side-effect from the INCREASE OF SPEED OF REPAIR from GH Pep is; pain and inflammation become Drastically reduced or non-existent for some.

11. The science behind why GH Pep is one of our best INJURY REPAIRers in the range is due to the following:

12. Our body running at its Full Optimal Potential would mean our Pituitary Gland would be functioning at its Full Optimal Potential. As stated earlier, one of Growth Hormone’s major role’s in the body is TISSUE FUNCTIONING. This Tissue Functioning includes the proper repair of the tissues involved in injury – including the micro-tears caused after a session of high-intensity training.

13. With Elite Sarms – GH Pep supporting your Pituitary Gland’s Optimum release of Growth Hormone, this also creates the Optimum environment for tissue repair resulting in less inflammation and pain each day when supplementing with GH Pep – another factor that becomes more important with age.

14. This makes Elite Sarms – GH Pep perfect for anyone that is looking for Rejuvenation of the body while at the same time benefiting from the awesome Physique and Performance results of the one and only: GH Pep


Posted on by — Leave a comment

WHAT ARE SARMS? LET’S START WITH THE BASICS.

Elite Sarms 1 bd694330 72ca 4253 8233 413a921a7c83

Consistent workouts, coupled with a balanced, nutritious diet and a deep healthy sleep act as the foundation for good fitness, but many athletes, weightlifters, and gym lovers often turn to supplements to give them extra edge to expedite their performance and body composition goals.

A topic we are most excited about (and for obvious reasons) are SARMs. SARMs are a little bit of an underdog in the supplement scene, but very much becoming a popularity amongst the rest. Why?! Because they deliver results, and fast. We live in a fast-paced world, filled with instant gratification. We all know how much dedication and discipline it takes it is to put on a few KG’s of muscle or visa versa, drop a few KG’s of body fat.

Selective Androgen Receptor Modulators

So, what are SARMs? Let’s start with the basics; SARM stands for Selective Androgen Receptor Modulators. They are a group of compounds that selectively target receptors in muscle, bone, connective tissue and body fat. This is due to the SARM being selective in its action. Each SARM targets different Androgen Receptors within the body, which mean it amplifies your body’s OWN natural response to exercise, and based on the type of SARM you might be taking.

Androgens are chemicals present in your body responsible for controlling the development and maintenance of characteristics like muscle growth and lowering fat stores in the body. Think about Androgens like a messenger that delivers the message to our cells to take a certain action in the body.

Because SARMs are selective in their action they will target specific area that require attention or are your focus point. That could be an increase of muscle mass, healing of a particular injury, regeneration of connective tissue, and or loss of fat. This is what makes our range of supplements so unique, making them an ideal choice for athletic performance and body building.

SARMs have become most effective non-toxic sports supplement amongst health-conscious bodybuilders, athletes who are singing praises for performance enhancement and muscle building purposes as well as increased metabolic rate and anti-ageing effects. Think about increased endurance during training and reduced recovery time post training sessions and for every one work out, equals an action of two as a result in the body.

At Elite Sarms we take pride in research, looking at the latest trends and finding what works best on the human body, not only for all our customers, but ourselves too. If you have any questions on how to take your performance or body further, were here to help.