Hacking Your Bioage With NAD+

By M.G. Thibault
Edited by Ryan McTeigue

Aging is a natural and organic process that everyone undergoes. Both our bodies and mind go through cycles of changes throughout our life. As we age, our cells have a lesser capacity to divide and multiply, some lose their function, and eventually deteriorate. This is the scientific meaning of ageing

The dilemmas that come with aging

As our age advances, wrinkles become more prominent in our skin, our hair thins and loses pigmentation, and our memory is not as retentive. More importantly, we feel a decrease in energy and strength; we become more susceptible to diseases, while abnormalities and dysfunction begin to show within our body.

So, when this article mentions about “hacking” your biological age, this means we are providing you with science-based information that leads to some adjustments in your lifestyle and diet, which can intervene with these signs and symptoms of aging.

The Role of “Nutrigenomics”

When we talk about Biohacking, we have to mention its close associate, “Nutrigenomics.” This term supports the idea that our body’s total genetic expression can be optimized by taking the right nutrients that influence our overall health over time.

The thing is, genes may be critical for determining inherent abilities, but Nutrition can modify the extent to which different genes are expressed and thus modifies whether an individual reaches the potential established by their genetic pre-disposition.

This emerging knowledge can transform nutrition and dietary practices to optimise health, promote longevity, and prevent or even treat certain diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121546/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137135/

First off, we’ll identify the “poor-quality” foods that induce inflammation. Some studies consider aging as a chronic inflammatory state, so one of the best anti-aging hacks would be to stop eating junk food (such as fried foods) and start incorporating more anti-oxidants and anti-inflammatory foods in your diet.

Avoid trans fats, that easily produce cancer-causing free radicals and literally slow the body down. It will also benefit you to refrain from eating too much sugar and processed carbohydrates (like pasta, bread, and pastries) as this may lead to chronically high insulin levels that positively correlate with age-related diseases including diabetes and heart diseases.

Treated meats like hot dogs, bacon, and pepperoni are usually high in nitrates, which also lead to inflammation. Moderate drinking (a 5-ounce glass of red wine per day, 5x a week) may be good for your heart, but heavy drinking will only speed up the aging process.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457053/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326908/

https://www.ncbi.nlm.nih.gov/pubmed/12070110

Boosting NAD+ levels

Nicotinamide Adenine Dinucleotide otherwise known as NAD+ is a chemical compound, which is found in essentially every cell of the body, and produced in abundance during adolescence all the way up to early adulthood. Its main function is to facilitate healthy brain function, regulate metabolism, repair damaged DNA, and strengthen our cell’s defences. Like most compounds secreted by the body, NAD+ levels start to decrease as we age.

Recent lab tests on animals have shown that raising NAD+ levels may help reverse signs of aging and reduce the incidence of many chronic diseases. You can boost your NAD+ levels by:

1. Exercise. Daily workouts require more NAD+ for energy, and your body responds to increased demand by producing it.

2. Raw foods that contain vitamin B, like avocados, steamed fish, whole grains, and nuts can boost NAD+ levels. Consider adding fermented foods and drinks to your diet like sauerkraut and kombucha. These are rich in NAD+ and also effective in easing persistent bloating and chronic joint pain.

3.Oral NAD+ supplements. One article shows that supplementation of Nicotinamide Riboside (NR, 500 mg, 2×/day), a NAD+ precursor, effectively stimulates NAD+ metabolism in healthy middle-aged and older adults.

4. NAD+ infusions. The Intravenous route promotes higher bioavailability, compared to oral supplements meaning a fuller dosage enters the body to help restore the mitochondria, and renew power at the cellular level. Specialised health and anti-aging clinics may have this available, shop around the internet to find one near you if you are interested.

https://www.nature.com/articles/s41467-018-03421-7

5. Growth Hormone Mimetics. GH Pep® (MK-677) is a growth hormone secretagogue, which amplifies the body’s natural release of growth hormone (GH) and insulin-like-growth-factor 1 (IGF-1). Among their many benefits such as lean muscle gains, accelerated fat loss, and tissue repair, the increase in GH and IGF-1 levels regulate mitochondrial mass and function and contribute significantly to mitochondrial biogenesis, respiration and ATP production.

How does this relate to boosting NAD+ levels?

A Study from the University of California demonstrates that the mitochondria in cells create NAD from the nicotinamide mononucleotide (NMN), one of its precursors. This explains why NAD+ levels decline with mitochondrial dysfunction aka slow metabolism and reduced NAD+/NADH ratio is implicated in mitochondrial disorders, as well as during aging.

As far as anti-aging goes, Elite Sarms product: GH Pep® (MK-677) is a remarkable anti-aging supplement since it not only boosts your growth hormone and IGF-1, sustaining your hormone profile in a state of perpetual youth, it also increases the production of your NAD+ which you now know is another Key Level Player in the quest for the fountain of youth.

https://www.elitesarms.com/products/gh-pep-mk677?_pos=1&_sid=0fa73c6c8&_ss=r

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/

https://www.mdpi.com/2073-4409/9/6/1384/htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013257/

https://clintransmed.springeropen.com/articles/10.1186/s40169-016-0104-7