Current Trends in Male Performance Enhancement: What Works

Sexual performance with Elite Sarms

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In our previous blog, we explored the best natural supplements to improve male performance in the bedroom, and the science behind their response in the body. In this article, we put the spotlight on the latest pharmaceutical products in the market of enhancing sexual performance and stamina in males.


PDE5 Inhibitors

Majority of the pharmaceutical compounds used to treat erectile dysfunction and enhance libido work by stimulating blood flow to the penis – similarly to how we use nitric oxide increasers in pre-workout to enhance our muscle pumps in the gym. Oral formulations of Phosphodiesterase type 5 (PDE5) inhibitors are the most common in this category and work to block the breakdown of cyclic guanosine monophosphate (cGMP). This prolongs the signalling of vasodilation molecules including; nitric oxide (NO) resulting in longer erections.

It is important to note that individuals who are taking nitrate drugs for chest pain or using alpha-blockers to treat high blood pressure should not take PDE5 inhibitors, as this can lead to a sudden decrease in blood pressure, which can become a danger.

https://pubmed.ncbi.nlm.nih.gov/31643519/ https://www.healthline.com/health/heart-disease/drugs https://www.healthline.com/health/high-blood-pressure-hypertension-medication


Sildenafil (Viagra) is a popular PDE5 inhibitor, mainly due to its shorter activation time and shorter half-life. A 2002 study showed that it takes roughly 27 minutes for Sildenafil to kick in. That is relatively fast if one is looking to be spontaneous in sexual activity.

Depending on individual metabolism, Sildenafil can take 4 to 6 hours to fully leave your system. For the most part, Sildenafil can be taken for on-demand usage but if you’re looking for a daily dosage, 50mg a day is considered a safe dose.



Tadalafil (Cialis) is another PDE5 inhibitor, but slightly different compared to Sildenafil. Tadalafil’s activation period takes 1-2 hours after taking it, meaning one will have to wait longer to get fired up. This is more suited to unplanned intimacies like a night out or weekend trips – in fact Tadalafil has been dubbed “The Weekender”.

Since Tadalafil takes longer to activate, this also means it has a longer half-life. Tadalafil has an active half-life for up to 17.5 hrs resulting in erectile responsiveness for up to 36 hours with a single dose! A 2016 study established its safety and efficacy whether taken as needed, or on a daily basis.

https://www.elitesarms.com/products/tadalafil?_pos=1&_sid=8145ab6b4&_ss=r https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411983/

Penile Suppositories

Alprostadil – Penile Suppository

Yes this a real thing! Alprostadil known as – MUSE – comes as a penile suppository, meaning it is placed in the urethra. MUSE, or (Medicated Urethral System for Erections), is available as a pill or injection. Alprostadil is in the vasodilator family of compounds. The pill version is inserted into the urethra, which is the opening at the tip of the penis and in 5-10 minutes, it activates by causing blood vessels to expand, by relaxing smooth muscle and allowing more blood flow into the shaft.

Despite Alprostadil’s maybe not-so-enjoyable application method, this is an important medication for males with Erectile dysfunction (ED) because it is usable by men suffering from diabetes or heart problems and those who have undergone a prostatectomy. It has no known interactions with food, alcohol or other medications making it safer than other treatments, such as the injection form, containing alprostadil.


Peptide Injections

PT-141 (Bremelanotide)

PT-141 is an FDA- approved injectable (stomach area) medication specifically effective for hypoactive sexual desire disorder (HSDD). This drug is different and exciting because it works directly on the hypothalamus in the brain to increase sexual desire. This makes it effective on men and just as effective on women, having a persistent or recurrent deficiency or absence of sexual fantasies, thoughts, and desire.

Think of it as an aphrodisiac that targets neural pathways of the brain to increase your libido…

For best effects, patients should inject PT-141 around 45 minutes before sexual activity. While this peptide carries huge potential in the treatment of erectile dysfunction and hypoactive sexual desire disorder (HSDD), it should not be used more than once in a 24 hour period or more than 8 times in a month – according to health professionals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819023/ https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-hypoactive-sexual-desire-disorder-premenopausal-women

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