Protect® (Tamoxifen): Combatting Estrogen Dominance for Effective Fat Loss

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By: M. G. Thibault

Hormones regulate many bodily functions in women, including sleep, stress, appetite, and libido, to name a few. It may be overwhelming to fully comprehend the hormone puzzle, and we are here to help you better understand how hormones work and how they can affect our bodies and health. Estrogen and progesterone are two of the most important hormones affecting women.

Estrogen is a female sex hormone and its primary function is to promote growth. It is especially important during puberty and pregnancy, and it plays a role in the menstrual cycle, bone strength, and fat distribution in the body.

Progesterone is a hormone secreted by the female reproductive system to regulate the uterine inner lining (endometrium), and plays an essential role in regulating the menstrual cycle and maintaining the early stages of pregnancy.

What is Estrogen Dominance?

Estrogen dominance occurs when there is an excess of estrogen in the body relative to other sex hormones. Estrogen dominance can cause abnormal menstruation (heavy/painful periods), fluid retention, headaches, decreased sex drive, bloating, mood swings, fatigue, anxiety & depression, breast tenderness, and hormonal weight gain. If you are experiencing some of these symptoms, excess estrogen is a big possibility. Let’s investigate further to know what’s causing this and how you can manage disproportionate levels of estrogen.

Factors Contributing to Estrogen Dominance

Insulin and cortisol imbalance: These two hormones regulate stress responses and blood sugar levels in the body, which can interfere with ovarian, thyroid, progesterone, testosterone, and sleep hormones.

Contraceptive Pills: The pill controls your hormones by preventing ovulation. However, if you do not ovulate, you do not produce progesterone, which can result in higher estrogen levels.

Poor liver function: estrogen is detoxified by the liver and then eliminated through the bowel. If our livers aren’t working properly and we’re not getting rid of the estrogen, it can lead to a buildup.

Weight gain: Because our fat cells can produce estrogen, the more fat we store, the higher our estrogen levels can rise.

Poor diet: To effectively metabolize estrogen, the body requires B vitamins, magnesium, zinc, omega-3 fatty acids, and protein. If you don’t get enough of these vitamins and minerals in your diet, your estrogen levels will rise.

Family genetics: Also play a role in estrogen production. Some women may produce too much estrogen without any negative symptoms, whereas others struggle greatly.

Chemical estrogens: ingested or absorbed through the skin, chemical estrogens such as BPA, pesticides, and beauty products can mimic our bodies’ own estrogen, causing levels to rise.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222987/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689796/

Managing Estrogen Dominance:

Liver support: avoiding substances toxic to the liver, particularly alcohol, in order to efficiently metabolize estrogen and facilitate its elimination.

Reduce your stress levels: to help balance your cortisol levels.

Manage insulin levels: by eating a diet low in processed sugar and carbohydrates.

Avoid chemical estrogens: by using BPA-free plastics or alternatives, switching to natural brands for toiletries and cosmetics, and going organic to reduce pesticide exposure.

Lose weight: remember less fat = less estrogen production.

Supplementation: we recommend taking supplements to help restore balance between your estrogen and progesterone levels.

Protect® (Tamoxifen) in Reducing the Effects of Estrogen Dominance

We talked about the use of supplements to facilitate a healthy estrogen balance and one of the most effective products currently available is Protect® (Tamoxifen). Classed as a selective estrogen receptor modulator or SERM, it is a non-steroidal anti-estrogen drug developed in the 1960’s to prevent breast cancer. By blocking the effects of estrogen in the body, it stops the proliferative effects caused by the hormone in certain cancers. Although initially used to treat breast cancer patients, it has gained popularity among fitness people and bodybuilders as a fat loss agent. The benefits of using tamoxifen to burn fat with minimal muscle wastage has made it popular as a fat burning agent in both healthcare and the fitness industry.

While Protect® (Tamoxifen) doesn’t directly promote weight loss, it can prevent estrogen-induced weight gain. Tamoxifen can help minimize the amount of receptors available for estrogen binding. Because of this, you’ll be less likely to add weight and you’ll have a better chance of losing stubborn fat around problem areas like the stomach, hips, thighs and triceps.

Upon binding to estrogen receptors, tamoxifen blocks the action of estrogen and significantly reduces the accumulation of adipose tissues. This is extremely important because as we mentioned, fat gain can be caused by high levels of estrogen in the body. By binding with these receptors, Protect® effectively inhibits these effects.

In a ground-breaking study, published in The Journal of the American Medical Association, researchers found that tamoxifen was proven to increase muscle mass and reduce body fat percentage in both men and women. Furthermore, the use of tamoxifen
is associated with improved cardiovascular health, which helps increase blood flow and aids in recovery from strenuous exercise.

If you are concerned about safety, it is important to note that SERMs don’t actually eliminate the estrogenic compounds in the body, meaning the risk of low estrogen related problems are severely reduced. Protect® does not carry the risk of totally eliminating a women’s estrogen, opening her up to joint and reproductive issues as well as a greater risk of virilization

For dosing recommendations, the typical dose for breast cancer patients is around 20-40 mg a day. You don’t need to take that much. Off-label use of Protect® (Tamoxifen) as a fat shredding agent is 10-20 mg a day, which is equivalent to .5-1ml daily.


If you want to burn body fat and get ripped more efficiently, give tamoxifen a try. This drug blocks the effects of excessive estrogen in your body, and exerts a direct effect on your body’s ability to lose stubborn body fat while preserving lean muscle mass. Protect® (Tamoxifen)  is fairly safe since it allows women to enjoy the physique benefits of a reduced estrogenic load without actually removing the estrogen, which is then free to perform other body functions.


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